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The recommended frequency of resistance training for major muscle groups is at least two non-consecutive days per week. This guidance is based on research and expert recommendations, including those from organizations like the American College of Sports Medicine. Training major muscle groups on two different days allows adequate recovery time for muscles to repair and grow, which is essential for strength development and injury prevention.

Additionally, training on non-consecutive days ensures that there is time for muscle recovery, which is vital for optimizing performance and results. This frequency strikes a balance between providing sufficient stimulation for muscle adaptation while allowing enough recovery time, thus promoting overall progress in strength and endurance.

In contrast, training major muscle groups once a week may not provide adequate frequency for those looking to maximize strength and hypertrophy. Daily resistance training without recovery can lead to overtraining and increase the risk of injury. Finally, training consecutively for three days would not allow for adequate recovery between sessions, which could hinder progress.